The circadian clock protein REVERBα inhibits pulmonary fibrosis development

Pulmonary inflammatory responses lie under circadian control; however, the importance of circadian mechanisms in the underlying fibrotic phenotype is not understood. Here, we identify a striking change to these mechanisms resulting in a gain of amplitude and lack of synchrony within pulmonary fibrot...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Cunningham, Peter S., Meijer, Peter, Nazgiewicz, Alicja, Anderson, Simon G., Borthwick, Lee A., Bagnall, James, Kitchen, Gareth B., Lodyga, Monika, Begley, Nicola, Venkateswaran, Rajamiyer V., Shah, Rajesh, Mercer, Paul F., Durrington, Hannah J., Henderson, Neil C., Piper-Hanley, Karen, Fisher, Andrew J., Chambers, Rachel C., Bechtold, David A., Gibbs, Julie E., Loudon, Andrew S., Rutter, Martin K., Hinz, Boris, Ray, David W., Blaikley, John F.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969503/
https://ncbi.nlm.nih.gov/pubmed/31879343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912109117
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