Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism

The nuclear receptor REVERBα is a core component of the circadian clock and proposed to be a dominant regulator of hepatic lipid metabolism. Using antibody-independent ChIP-sequencing of REVERBα in mouse liver, we reveal a high-confidence cistrome and define direct target genes. REVERBα-binding site...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hunter, A. Louise, Pelekanou, Charlotte E., Adamson, Antony, Downton, Polly, Barron, Nichola J., Cornfield, Thomas, Poolman, Toryn M., Humphreys, Neil, Cunningham, Peter S., Hodson, Leanne, Loudon, Andrew S. I., Iqbal, Mudassar, Bechtold, David A., Ray, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568238/
https://ncbi.nlm.nih.gov/pubmed/32989157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005330117
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