Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism

The nuclear receptor REVERBα is a core component of the circadian clock and proposed to be a dominant regulator of hepatic lipid metabolism. Using antibody-independent ChIP-sequencing of REVERBα in mouse liver, we reveal a high-confidence cistrome and define direct target genes. REVERBα-binding site...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Hunter, A. Louise, Pelekanou, Charlotte E., Adamson, Antony, Downton, Polly, Barron, Nichola J., Cornfield, Thomas, Poolman, Toryn M., Humphreys, Neil, Cunningham, Peter S., Hodson, Leanne, Loudon, Andrew S. I., Iqbal, Mudassar, Bechtold, David A., Ray, David W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568238/
https://ncbi.nlm.nih.gov/pubmed/32989157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005330117
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