REVERBa couples the circadian clock to hepatic glucocorticoid action

The glucocorticoid receptor (GR) is a major drug target in inflammatory disease. However, chronic glucocorticoid (GC) treatment leads to disordered energy metabolism, including increased weight gain, adiposity, and hepatosteatosis — all programs modulated by the circadian clock. We demonstrated that...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Caratti, Giorgio, Iqbal, Mudassar, Hunter, Louise, Kim, Donghwan, Wang, Ping, Vonslow, Ryan M., Begley, Nicola, Tetley, Abigail J., Woodburn, Joanna L., Pariollaud, Marie, Maidstone, Robert, Donaldson, Ian J., Zhang, Zhenguang, Ince, Louise M., Kitchen, Gareth, Baxter, Matthew, Poolman, Toryn M., Daniels, Dion A., Stirling, David R., Brocker, Chad, Gonzalez, Frank, Loudon, Andrew S.I., Bechtold, David A., Rattray, Magnus, Matthews, Laura C., Ray, David W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2018
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160001/
https://ncbi.nlm.nih.gov/pubmed/30179226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96138
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