REVERBa couples the circadian clock to hepatic glucocorticoid action

The glucocorticoid receptor (GR) is a major drug target in inflammatory disease. However, chronic glucocorticoid (GC) treatment leads to disordered energy metabolism, including increased weight gain, adiposity, and hepatosteatosis — all programs modulated by the circadian clock. We demonstrated that...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Clin Invest
المؤلفون الرئيسيون: Caratti, Giorgio, Iqbal, Mudassar, Hunter, Louise, Kim, Donghwan, Wang, Ping, Vonslow, Ryan M., Begley, Nicola, Tetley, Abigail J., Woodburn, Joanna L., Pariollaud, Marie, Maidstone, Robert, Donaldson, Ian J., Zhang, Zhenguang, Ince, Louise M., Kitchen, Gareth, Baxter, Matthew, Poolman, Toryn M., Daniels, Dion A., Stirling, David R., Brocker, Chad, Gonzalez, Frank, Loudon, Andrew S.I., Bechtold, David A., Rattray, Magnus, Matthews, Laura C., Ray, David W.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2018
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160001/
https://ncbi.nlm.nih.gov/pubmed/30179226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96138
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