The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia. Infected mice show both red...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Kitchen, Gareth B., Cunningham, Peter S., Poolman, Toryn M., Iqbal, Mudassar, Maidstone, Robert, Baxter, Matthew, Bagnall, James, Begley, Nicola, Saer, Ben, Hussell, Tracy, Matthews, Laura C., Dockrell, David H., Durrington, Hannah J., Gibbs, Julie E., Blaikley, John F., Loudon, Andrew S., Ray, David W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2020
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983378/
https://ncbi.nlm.nih.gov/pubmed/31900362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915932117
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