The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity

Therapeutic monoclonal antibodies are the fastest growing class of biological therapeutics for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy, some IgG1 antibodies rely on the Fc-mediated immune effector function, antibody-dependent cellular cytotoxicity (ADCC),...

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Veröffentlicht in:MAbs
Hauptverfasser: Pereira, Natasha A., Chan, Kah Fai, Lin, Pao Chun, Song, Zhiwei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150623/
https://ncbi.nlm.nih.gov/pubmed/29733746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1466767
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