Attenuated glutamine synthetase as a selection marker in CHO cells to efficiently isolate highly productive stable cells for the production of antibodies and other biologics

Chinese hamster ovary (CHO) cells are the biopharmaceutical industry’s primary means of manufacturing therapeutic proteins, including monoclonal antibodies. The major challenge in cell line development for the production of recombinant biopharmaceuticals lies in generating and isolating rare high-pr...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Lin, Pao-Chun, Chan, Kah Fai, Kiess, Irene A., Tan, Joselyn, Shahreel, Wahyu, Wong, Sze-Yue, Song, Zhiwei
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601560/
https://ncbi.nlm.nih.gov/pubmed/31043114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1612690
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