Glutamine Synthetase in Muscle Is Required for Glutamine Production during Fasting and Extrahepatic Ammonia Detoxification

The main endogenous source of glutamine is de novo synthesis in striated muscle via the enzyme glutamine synthetase (GS). The mice in which GS is selectively but completely eliminated from striated muscle with the Cre-loxP strategy (GS-KO/M mice) are, nevertheless, healthy and fertile. Compared with...

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Detalhes bibliográficos
Main Authors: He, Youji, Hakvoort, Theodorus B. M., Köhler, S. Eleonore, Vermeulen, Jacqueline L. M., de Waart, D. Rudi, de Theije, Chiel, ten Have, Gabrie A. M., van Eijk, Hans M. H., Kunne, Cindy, Labruyere, Wilhelmina T., Houten, Sander M., Sokolovic, Milka, Ruijter, Jan M., Deutz, Nicolaas E. P., Lamers, Wouter H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843202/
https://ncbi.nlm.nih.gov/pubmed/20064933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092429
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