Glutamine Synthetase in Muscle Is Required for Glutamine Production during Fasting and Extrahepatic Ammonia Detoxification

The main endogenous source of glutamine is de novo synthesis in striated muscle via the enzyme glutamine synthetase (GS). The mice in which GS is selectively but completely eliminated from striated muscle with the Cre-loxP strategy (GS-KO/M mice) are, nevertheless, healthy and fertile. Compared with...

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Bibliografiska uppgifter
Huvudupphovsmän: He, Youji, Hakvoort, Theodorus B. M., Köhler, S. Eleonore, Vermeulen, Jacqueline L. M., de Waart, D. Rudi, de Theije, Chiel, ten Have, Gabrie A. M., van Eijk, Hans M. H., Kunne, Cindy, Labruyere, Wilhelmina T., Houten, Sander M., Sokolovic, Milka, Ruijter, Jan M., Deutz, Nicolaas E. P., Lamers, Wouter H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Metabolism
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843202/
https://ncbi.nlm.nih.gov/pubmed/20064933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092429
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