The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity

Therapeutic monoclonal antibodies are the fastest growing class of biological therapeutics for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy, some IgG1 antibodies rely on the Fc-mediated immune effector function, antibody-dependent cellular cytotoxicity (ADCC),...

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Vydáno v:MAbs
Hlavní autoři: Pereira, Natasha A., Chan, Kah Fai, Lin, Pao Chun, Song, Zhiwei
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150623/
https://ncbi.nlm.nih.gov/pubmed/29733746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1466767
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