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The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity

Therapeutic monoclonal antibodies are the fastest growing class of biological therapeutics for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy, some IgG1 antibodies rely on the Fc-mediated immune effector function, antibody-dependent cellular cytotoxicity (ADCC),...

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Publicat a:MAbs
Autors principals: Pereira, Natasha A., Chan, Kah Fai, Lin, Pao Chun, Song, Zhiwei
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150623/
https://ncbi.nlm.nih.gov/pubmed/29733746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1466767
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