Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design

Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesise cysteine. Reduction of virulence and decrease in antibiotic resistance have already been associated with mutations on the genes that codify cysteine biosynthetic enzymes. Therefore, inhibition of cy...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Magalhães, Joana, Franko, Nina, Annunziato, Giannamaria, Welch, Martin, Dolan, Stephen K., Bruno, Agostino, Mozzarelli, Andrea, Armao, Stefano, Jirgensons, Aigars, Pieroni, Marco, Costantino, Gabriele, Campanini, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147075/
https://ncbi.nlm.nih.gov/pubmed/30221554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1512596
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados