Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor

[Image: see text] In ϒ-proteobacteria and Actinomycetales, cysteine biosynthetic enzymes are indispensable during persistence and become dispensable during growth or acute infection. The biosynthetic machinery required to convert inorganic sulfur into cysteine is absent in mammals; therefore, it is...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Magalhães, Joana, Franko, Nina, Raboni, Samanta, Annunziato, Giannamaria, Tammela, Päivi, Bruno, Agostino, Bettati, Stefano, Mozzarelli, Andrea, Pieroni, Marco, Campanini, Barbara, Costantino, Gabriele
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236226/
https://ncbi.nlm.nih.gov/pubmed/32435386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00627
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