Linkage disequilibrium dependent architecture of human complex traits shows action of negative selection

Recent work has hinted at the linkage disequilibrium (LD) dependent architecture of human complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability. Here, we analyzed summary statistics from 56 complex traits (average N=101,401) by extending stratified LD score regressi...

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Bibliographic Details
Published in:Nat Genet
Main Authors: Gazal, Steven, Finucane, Hilary K., Furlotte, Nicholas A, Loh, Po-Ru, Palamara, Pier Francesco, Liu, Xuanyao, Schoech, Armin, Bulik-Sullivan, Brendan, Neale, Benjamin M, Gusev, Alexander, Price, Alkes L.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133304/
https://ncbi.nlm.nih.gov/pubmed/28892061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3954
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