Linkage disequilibrium dependent architecture of human complex traits shows action of negative selection

Recent work has hinted at the linkage disequilibrium (LD) dependent architecture of human complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability. Here, we analyzed summary statistics from 56 complex traits (average N=101,401) by extending stratified LD score regressi...

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Publicat a:Nat Genet
Autors principals: Gazal, Steven, Finucane, Hilary K., Furlotte, Nicholas A, Loh, Po-Ru, Palamara, Pier Francesco, Liu, Xuanyao, Schoech, Armin, Bulik-Sullivan, Brendan, Neale, Benjamin M, Gusev, Alexander, Price, Alkes L.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133304/
https://ncbi.nlm.nih.gov/pubmed/28892061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3954
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