Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits

There is increasing evidence that many GWAS risk loci are molecular QTL (eQTL, hQTL, sQTL, and/or meQTL). Here, we introduce a new set of functional annotations based on causal posterior probabilities of fine-mapped molecular cis-QTL, using data from the GTEx and BLUEPRINT consortia. We show that th...

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Publicat a:Nat Genet
Autors principals: Hormozdiari, Farhad, Gazal, Steven, van de Geijn, Bryce, Finucane, Hilary, Ju, Chelsea J.-T., Loh, Po-Ru, Schoech, Armin, Reshef, Yakir, Liu, Xuanyao, O’Connor, Luke, Gusev, Alexander, Eskin, Eleazar, Price, Alkes L.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030458/
https://ncbi.nlm.nih.gov/pubmed/29942083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0148-2
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