載入...

Extreme Polygenicity of Complex Traits Is Explained by Negative Selection

Complex traits and common diseases are extremely polygenic, their heritability spread across thousands of loci. One possible explanation is that thousands of genes and loci have similarly important biological effects when mutated. However, we hypothesize that for most complex traits, relatively few...

全面介紹

Na minha lista:
書目詳細資料
發表在:Am J Hum Genet
Main Authors: O'Connor, Luke J., Schoech, Armin P., Hormozdiari, Farhad, Gazal, Steven, Patterson, Nick, Price, Alkes L.
格式: Artigo
語言:Inglês
出版: Elsevier 2019
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732528/
https://ncbi.nlm.nih.gov/pubmed/31402091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2019.07.003
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!