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Extreme Polygenicity of Complex Traits Is Explained by Negative Selection
Complex traits and common diseases are extremely polygenic, their heritability spread across thousands of loci. One possible explanation is that thousands of genes and loci have similarly important biological effects when mutated. However, we hypothesize that for most complex traits, relatively few...
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| Published in: | Am J Hum Genet |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Elsevier
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6732528/ https://ncbi.nlm.nih.gov/pubmed/31402091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2019.07.003 |
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