Extreme Polygenicity of Complex Traits Is Explained by Negative Selection

Complex traits and common diseases are extremely polygenic, their heritability spread across thousands of loci. One possible explanation is that thousands of genes and loci have similarly important biological effects when mutated. However, we hypothesize that for most complex traits, relatively few...

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Bibliographic Details
Published in:	Am J Hum Genet
Main Authors:	O'Connor, Luke J., Schoech, Armin P., Hormozdiari, Farhad, Gazal, Steven, Patterson, Nick, Price, Alkes L.
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2019
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6732528/ https://ncbi.nlm.nih.gov/pubmed/31402091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2019.07.003
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Extreme Polygenicity of Complex Traits Is Explained by Negative Selection

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