Cargando...
Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
Understanding the role of rare variants is important in elucidating the genetic basis of human disease. Negative selection can cause rare variants to have larger per-allele effect sizes than common variants. Here, we develop a method to estimate the minor allele frequency (MAF) dependence of SNP eff...
Guardado en:
| Publicado en: | Nat Commun |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
|
| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6377669/ https://ncbi.nlm.nih.gov/pubmed/30770844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08424-6 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|