Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

Understanding the role of rare variants is important in elucidating the genetic basis of human disease. Negative selection can cause rare variants to have larger per-allele effect sizes than common variants. Here, we develop a method to estimate the minor allele frequency (MAF) dependence of SNP eff...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Schoech, Armin P., Jordan, Daniel M., Loh, Po-Ru, Gazal, Steven, O’Connor, Luke J., Balick, Daniel J., Palamara, Pier F., Finucane, Hilary K., Sunyaev, Shamil R., Price, Alkes L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377669/
https://ncbi.nlm.nih.gov/pubmed/30770844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08424-6
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