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Functional architecture of low-frequency variants highlights strength of negative selection across coding and noncoding annotations
Common variant heritability has been widely reported to be concentrated in variants within cell-type-specific noncoding functional annotations, but little is known about low-frequency variant functional architectures. We partitioned the heritability of both low-frequency (0.5%≤MAF<5%) and common...
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| Published in: | Nat Genet |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6236676/ https://ncbi.nlm.nih.gov/pubmed/30297966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0231-8 |
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