Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis

Neurotropic strains of mouse hepatitis virus (MHV) induce acute inflammation and chronic demyelination in the spinal cord and optic nerves mediated by axonal spread following intracranial inoculation in mice, with pathologic features similar to the human demyelinating disease multiple sclerosis. Spi...

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Dades bibliogràfiques
Publicat a:Front Cell Infect Microbiol
Autors principals: Singh, Manmeet, Khan, Reas S., Dine, Kimberly, Das Sarma, Jayasri, Shindler, Kenneth S.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Cellular and Infection Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132074/
https://ncbi.nlm.nih.gov/pubmed/30234031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00311
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