Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis

Neurotropic strains of mouse hepatitis virus (MHV) induce acute inflammation and chronic demyelination in the spinal cord and optic nerves mediated by axonal spread following intracranial inoculation in mice, with pathologic features similar to the human demyelinating disease multiple sclerosis. Spi...

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Bibliografski detalji
Izdano u:Front Cell Infect Microbiol
Glavni autori: Singh, Manmeet, Khan, Reas S., Dine, Kimberly, Das Sarma, Jayasri, Shindler, Kenneth S.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Cellular and Infection Microbiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132074/
https://ncbi.nlm.nih.gov/pubmed/30234031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00311
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