Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis

Neurotropic strains of mouse hepatitis virus (MHV) induce acute inflammation and chronic demyelination in the spinal cord and optic nerves mediated by axonal spread following intracranial inoculation in mice, with pathologic features similar to the human demyelinating disease multiple sclerosis. Spi...

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Bibliografiska uppgifter
I publikationen:Front Cell Infect Microbiol
Huvudupphovsmän: Singh, Manmeet, Khan, Reas S., Dine, Kimberly, Das Sarma, Jayasri, Shindler, Kenneth S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2018
Ämnen:
Cellular and Infection Microbiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132074/
https://ncbi.nlm.nih.gov/pubmed/30234031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00311
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