Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis

Neurotropic strains of mouse hepatitis virus (MHV) induce acute inflammation and chronic demyelination in the spinal cord and optic nerves mediated by axonal spread following intracranial inoculation in mice, with pathologic features similar to the human demyelinating disease multiple sclerosis. Spi...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Infect Microbiol
Hauptverfasser: Singh, Manmeet, Khan, Reas S., Dine, Kimberly, Das Sarma, Jayasri, Shindler, Kenneth S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Cellular and Infection Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132074/
https://ncbi.nlm.nih.gov/pubmed/30234031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00311
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