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Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis

The ability of novel mitochondrial uncoupler prodrug of 2,4-dinitrophenol (DNP), MP201, to prevent neuronal damage and preserve visual function in an experimental autoimmune encephalomyelitis (EAE) model of optic neuritis was evaluated. Optic nerve inflammation, demyelination, and axonal loss are pr...

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Опубликовано в: :Oxid Med Cell Longev
Главные авторы: Khan, Reas S., Dine, Kimberly, Geisler, John G., Shindler, Kenneth S.
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478871/
https://ncbi.nlm.nih.gov/pubmed/28680531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/7180632
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