High expression of CD44v9 and xCT in chemoresistant hepatocellular carcinoma: Potential targets by sulfasalazine

CD44v9 is expressed in cancer stem cells (CSC) and stabilizes the glutamate‐cystine transporter xCT on the cytoplasmic membrane, thereby decreasing intracellular levels of reactive oxygen species (ROS). This mechanism confers ROS resistance to CSC and CD44v9‐expressing cancer cells. The aims of the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer Sci
Hauptverfasser: Wada, Fumitaka, Koga, Hironori, Akiba, Jun, Niizeki, Takashi, Iwamoto, Hideki, Ikezono, Yu, Nakamura, Toru, Abe, Mitsuhiko, Masuda, Atsutaka, Sakaue, Takahiko, Tanaka, Toshimitsu, Kakuma, Tatsuyuki, Yano, Hirohisa, Torimura, Takuji
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125439/
https://ncbi.nlm.nih.gov/pubmed/29981246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13728
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge