High expression of CD44v9 and xCT in chemoresistant hepatocellular carcinoma: Potential targets by sulfasalazine

CD44v9 is expressed in cancer stem cells (CSC) and stabilizes the glutamate‐cystine transporter xCT on the cytoplasmic membrane, thereby decreasing intracellular levels of reactive oxygen species (ROS). This mechanism confers ROS resistance to CSC and CD44v9‐expressing cancer cells. The aims of the...

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Bibliografiske detaljer
Udgivet i:Cancer Sci
Main Authors: Wada, Fumitaka, Koga, Hironori, Akiba, Jun, Niizeki, Takashi, Iwamoto, Hideki, Ikezono, Yu, Nakamura, Toru, Abe, Mitsuhiko, Masuda, Atsutaka, Sakaue, Takahiko, Tanaka, Toshimitsu, Kakuma, Tatsuyuki, Yano, Hirohisa, Torimura, Takuji
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125439/
https://ncbi.nlm.nih.gov/pubmed/29981246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13728
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