Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces “angiogenic switch off” in a hepatoma mouse model

“Angiogenic switch off” is one of the ideal therapeutic concepts in the treatment of cancer. However, the specific molecules which can induce “angiogenic switch off” in tumor have not been identified yet. In this study, we focused on von Hippel-Lindau protein (pVHL) in hepatocellular carcinoma (HCC)...

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Опубликовано в: :Mol Ther Oncolytics
Главные авторы: Iwamoto, Hideki, Nakamura, Toru, Koga, Hironori, Izaguirre-Carbonell, Jesus, Kamisuki, Shinji, Sugawara, Fumio, Abe, Mitsuhiko, Iwabata, Kazuki, Ikezono, Yu, Sakaue, Takahiko, Masuda, Atsutaka, Yano, Hirohisa, Ohta, Keisuke, Nakano, Masahito, Shimose, Shigeo, Shirono, Tomotake, Torimura, Takuji
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782957/
https://ncbi.nlm.nih.gov/pubmed/27119112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2015.20
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