Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces “angiogenic switch off” in a hepatoma mouse model

“Angiogenic switch off” is one of the ideal therapeutic concepts in the treatment of cancer. However, the specific molecules which can induce “angiogenic switch off” in tumor have not been identified yet. In this study, we focused on von Hippel-Lindau protein (pVHL) in hepatocellular carcinoma (HCC)...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Iwamoto, Hideki, Nakamura, Toru, Koga, Hironori, Izaguirre-Carbonell, Jesus, Kamisuki, Shinji, Sugawara, Fumio, Abe, Mitsuhiko, Iwabata, Kazuki, Ikezono, Yu, Sakaue, Takahiko, Masuda, Atsutaka, Yano, Hirohisa, Ohta, Keisuke, Nakano, Masahito, Shimose, Shigeo, Shirono, Tomotake, Torimura, Takuji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782957/
https://ncbi.nlm.nih.gov/pubmed/27119112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2015.20
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