High expression of CD44v9 and xCT in chemoresistant hepatocellular carcinoma: Potential targets by sulfasalazine

CD44v9 is expressed in cancer stem cells (CSC) and stabilizes the glutamate‐cystine transporter xCT on the cytoplasmic membrane, thereby decreasing intracellular levels of reactive oxygen species (ROS). This mechanism confers ROS resistance to CSC and CD44v9‐expressing cancer cells. The aims of the...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Wada, Fumitaka, Koga, Hironori, Akiba, Jun, Niizeki, Takashi, Iwamoto, Hideki, Ikezono, Yu, Nakamura, Toru, Abe, Mitsuhiko, Masuda, Atsutaka, Sakaue, Takahiko, Tanaka, Toshimitsu, Kakuma, Tatsuyuki, Yano, Hirohisa, Torimura, Takuji
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125439/
https://ncbi.nlm.nih.gov/pubmed/29981246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13728
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