Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding

Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by activating the transcription factor (TF) activity of glucocorticoid receptor (GR). Previous models have proposed that DNA binding motifs and sites of chromatin accessibility predetermine GR binding and activity. How...

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Pubblicato in:Genome Res
Autori principali: McDowell, Ian C., Barrera, Alejandro, D'Ippolito, Anthony M., Vockley, Christopher M., Hong, Linda K., Leichter, Sarah M., Bartelt, Luke C., Majoros, William H., Song, Lingyun, Safi, Alexias, Koçak, D. Dewran, Gersbach, Charles A., Hartemink, Alexander J., Crawford, Gregory E., Engelhardt, Barbara E., Reddy, Timothy E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120625/
https://ncbi.nlm.nih.gov/pubmed/30097539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.233346.117
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