Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

Genome engineering technologies based on the CRISPR/Cas9 and TALE systems are enabling new approaches in science and biotechnology. However, the specificity of these tools in complex genomes and the role of chromatin structure in determining DNA binding are not well understood. We analyzed the genom...

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Detaylı Bibliyografya
Yayımlandı:Genome Res
Asıl Yazarlar: Polstein, Lauren R., Perez-Pinera, Pablo, Kocak, D. Dewran, Vockley, Christopher M., Bledsoe, Peggy, Song, Lingyun, Safi, Alexias, Crawford, Gregory E., Reddy, Timothy E., Gersbach, Charles A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2015
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510000/
https://ncbi.nlm.nih.gov/pubmed/26025803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.179044.114
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