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A light-inducible CRISPR/Cas9 system for control of endogenous gene activation
Optogenetic systems enable precise spatial and temporal control of cell behavior. We engineered a light-activated CRISPR/Cas9 effector (LACE) system that induces transcription of endogenous genes in the presence of blue light. This was accomplished by fusing the light-inducible heterodimerizing prot...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4412021/ https://ncbi.nlm.nih.gov/pubmed/25664691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1753 |
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