Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

Genome engineering technologies based on the CRISPR/Cas9 and TALE systems are enabling new approaches in science and biotechnology. However, the specificity of these tools in complex genomes and the role of chromatin structure in determining DNA binding are not well understood. We analyzed the genom...

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Veröffentlicht in:Genome Res
Hauptverfasser: Polstein, Lauren R., Perez-Pinera, Pablo, Kocak, D. Dewran, Vockley, Christopher M., Bledsoe, Peggy, Song, Lingyun, Safi, Alexias, Crawford, Gregory E., Reddy, Timothy E., Gersbach, Charles A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510000/
https://ncbi.nlm.nih.gov/pubmed/26025803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.179044.114
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