Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

Genome engineering technologies based on the CRISPR/Cas9 and TALE systems are enabling new approaches in science and biotechnology. However, the specificity of these tools in complex genomes and the role of chromatin structure in determining DNA binding are not well understood. We analyzed the genom...

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Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: Polstein, Lauren R., Perez-Pinera, Pablo, Kocak, D. Dewran, Vockley, Christopher M., Bledsoe, Peggy, Song, Lingyun, Safi, Alexias, Crawford, Gregory E., Reddy, Timothy E., Gersbach, Charles A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510000/
https://ncbi.nlm.nih.gov/pubmed/26025803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.179044.114
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