Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding

Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by activating the transcription factor (TF) activity of glucocorticoid receptor (GR). Previous models have proposed that DNA binding motifs and sites of chromatin accessibility predetermine GR binding and activity. How...

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Vydáno v:Genome Res
Hlavní autoři: McDowell, Ian C., Barrera, Alejandro, D'Ippolito, Anthony M., Vockley, Christopher M., Hong, Linda K., Leichter, Sarah M., Bartelt, Luke C., Majoros, William H., Song, Lingyun, Safi, Alexias, Koçak, D. Dewran, Gersbach, Charles A., Hartemink, Alexander J., Crawford, Gregory E., Engelhardt, Barbara E., Reddy, Timothy E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120625/
https://ncbi.nlm.nih.gov/pubmed/30097539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.233346.117
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