Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder initiated by antibodies to platelet factor 4 (PF4)/heparin complexes. PF4 released from platelets binds to surface glycosaminoglycans on hematopoietic and vascular cells that are heterogenous in composition and differ in affinity for...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Dai, Jing, Madeeva, Daria, Hayes, Vincent, Ahn, Hyun Sook, Tutwiler, Valerie, Arepally, Gowthami M., Cines, Douglas B., Poncz, Mortimer, Rauova, Lubica
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097133/
https://ncbi.nlm.nih.gov/pubmed/29914979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-02-830737
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