Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications

Heparin-induced thrombocytopenia (HIT) antibodies recognize complexes between heparin and platelet factor 4 (PF4). Heparin and PF4 bind HIT antibodies only over a narrow molar ratio. We explored the involvement of platelet surface–bound PF4 as an antigen in the pathogenesis of experimental HIT. We s...

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Bibliographic Details
Main Authors: Rauova, Lubica, Zhai, Li, Kowalska, M. Anna, Arepally, Gowthami M., Cines, Douglas B., Poncz, Mortimer
Format: Artigo
Language:Inglês
Published: The American Society of Hematology 2006
Subjects:
Hemostasis, Thrombosis, and Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895727/
https://ncbi.nlm.nih.gov/pubmed/16304054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3122
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