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Determinants of PF4/heparin immunogenicity
Heparin-induced thrombocytopenia (HIT) is an antibody-mediated disorder that occurs with variable frequency in patients exposed to heparin. HIT antibodies preferentially recognize large macromolecular complexes formed between PF4 and heparin over a narrow range of molar ratios, but the biophysical p...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Hematology
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234783/ https://ncbi.nlm.nih.gov/pubmed/17848616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-08-105098 |
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