Determinants of PF4/heparin immunogenicity

Heparin-induced thrombocytopenia (HIT) is an antibody-mediated disorder that occurs with variable frequency in patients exposed to heparin. HIT antibodies preferentially recognize large macromolecular complexes formed between PF4 and heparin over a narrow range of molar ratios, but the biophysical p...

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Detalhes bibliográficos
Main Authors: Suvarna, Shayela, Espinasse, Benjamin, Qi, Rui, Lubica, Rauova, Poncz, Mortimer, Cines, Douglas B., Wiesner, Mark R., Arepally, Gowthami M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234783/
https://ncbi.nlm.nih.gov/pubmed/17848616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-08-105098
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