Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation

Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by complexes between platelet factor 4 (PF4) and heparin or other polyanions, but the risk of thrombosis extends beyond exposure to heparin implicating other PF4 partners. We recently reported that peri-thrombus endothelium...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Johnston, Ian, Sarkar, Amrita, Hayes, Vincent, Koma, Gavin T., Arepally, Gowthami M., Chen, Junmei, Chung, Dominic W., López, José A., Cines, Douglas B., Rauova, Lubica, Poncz, Mortimer
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7146020/
https://ncbi.nlm.nih.gov/pubmed/32077913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018881607
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