Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT

Heparin-induced thrombocytopenia (HIT) is caused by antibodies that recognize complexes between platelet factor 4 (PF4) and heparin or glycosaminoglycan side chains. These antibodies can lead to a limb- and life-threatening prothrombotic state. We now show that HIT antibodies are able to inhibit gen...

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Detalhes bibliográficos
Main Authors: Kowalska, M. Anna, Krishnaswamy, Sriram, Rauova, Lubica, Zhai, Li, Hayes, Vincent, Amirikian, Karine, Esko, Jeffrey D., Bougie, Daniel W., Aster, Richard H., Cines, Douglas B., Poncz, Mortimer
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172804/
https://ncbi.nlm.nih.gov/pubmed/21772054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-335208
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