Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is characterized by a high incidence of thrombosis, unlike other antibody-mediated causes of thrombocytopenia. We have shown that monocytes complexed with surface-bound platelet factor 4 (PF4) activated by HIT antibodies contribute to the prothrombotic state in...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Tutwiler, Valerie, Madeeva, Daria, Ahn, Hyun Sook, Andrianova, Izabella, Hayes, Vincent, Zheng, X. Long, Cines, Douglas B., McKenzie, Steven E., Poncz, Mortimer, Rauova, Lubica
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731847/
https://ncbi.nlm.nih.gov/pubmed/26518435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-11-539262
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