Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis

Myocardial fibrosis and the resultant increases in left ventricular stiffness represent pivotal consequences of chronic pressure overload (PO) that impact both functional capacity and the rates of morbid and mortal events. However, the time course and cellular mechanisms that underlie PO-induced fib...

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Publicat a:Am J Physiol Heart Circ Physiol
Autors principals: McDonald, Lindsay T., Zile, Michael R., Zhang, Yuhua, Van Laer, An O., Baicu, Catalin F., Stroud, Robert E., Jones, Jeffrey A., LaRue, Amanda C., Bradshaw, Amy D.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087775/
https://ncbi.nlm.nih.gov/pubmed/29522370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00719.2017
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