Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis

Myocardial fibrosis and the resultant increases in left ventricular stiffness represent pivotal consequences of chronic pressure overload (PO) that impact both functional capacity and the rates of morbid and mortal events. However, the time course and cellular mechanisms that underlie PO-induced fib...

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Bibliographic Details
Published in:Am J Physiol Heart Circ Physiol
Main Authors: McDonald, Lindsay T., Zile, Michael R., Zhang, Yuhua, Van Laer, An O., Baicu, Catalin F., Stroud, Robert E., Jones, Jeffrey A., LaRue, Amanda C., Bradshaw, Amy D.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087775/
https://ncbi.nlm.nih.gov/pubmed/29522370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00719.2017
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