Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing

Advanced age, independent of concurrent cardiovascular disease, can be associated with increased extracellular matrix (ECM) fibrillar collagen content and abnormal diastolic function. However, the mechanisms causing this left ventricular (LV) remodeling remain incompletely defined. We hypothesized t...

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Autori principali: Bradshaw, Amy D., Baicu, Catalin F., Rentz, Tyler J., Van Laer, An O., Bonnema, D. Dirk, Zile, Michael R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2010
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822576/
https://ncbi.nlm.nih.gov/pubmed/20008277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00474.2009
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