Pressure-Overload Induced Alterations in Fibrillar Collagen Content and Myocardial Diastolic Function: Role of SPARC in Post-Synthetic Procollagen Processing

BACKGROUND: Chronic pressure-overload (PO) causes myocardial hypertrophy, increased fibrillar collagen content, and abnormal diastolic function. We hypothesized that one determinant of these PO-induced changes is the extracellular processing of newly synthesized procollagen into mature collagen fibr...

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Detalhes bibliográficos
Main Authors: Bradshaw, Amy D., Baicu, Catalin F., Rentz, Tyler J., Van Laer, An O., Boggs, Janet, Lacy, John M., Zile, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734276/
https://ncbi.nlm.nih.gov/pubmed/19118257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.773424
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