SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload

In human heart failure and in murine hearts with left-ventricular pressure overload (LVPO), increases in fibrosis are associated with increases in myocardial stiffness. Secreted protein acidic and rich in cysteine (SPARC) is shown to be necessary for both cardiac fibrosis and increases in myocardial...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Riley, Hannah J., Kelly, Ryan R., Van Laer, An O., Neff, Lily S., Dasgupta, Shaoni, Baicu, Catalin F., McDonald, Lindsay T., LaRue, Amanda C., Zile, Michael R., Bradshaw, Amy D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082795/
https://ncbi.nlm.nih.gov/pubmed/33306449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00552.2020
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