Endocytosis is required for CXC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling

Signaling activated by binding of the CXC motif chemokine ligand 12 (CXCL12) to its cognate G protein–coupled receptor (GPCR), chemokine CXC motif receptor 4 (CXCR4), is linked to metastatic disease. However, the mechanisms governing CXCR4 signaling remain poorly understood. Here, we show that endoc...

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Vydáno v:J Biol Chem
Hlavní autoři: English, Elizabeth J., Mahn, Sarah A., Marchese, Adriano
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065176/
https://ncbi.nlm.nih.gov/pubmed/29899118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001872
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