Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices

The atomic-level mechanisms by which G protein-coupled receptors (GPCRs) transmit extracellular ligand binding events through their transmembrane helices to activate intracellular G proteins remain unclear. Using a comprehensive library of mutations covering all 352 residues of the GPCR CXC chemokin...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wescott, Melanie P., Kufareva, Irina, Paes, Cheryl, Goodman, Jason R., Thaker, Yana, Puffer, Bridget A., Berdougo, Eli, Rucker, Joseph B., Handel, Tracy M., Doranz, Benjamin J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024644/
https://ncbi.nlm.nih.gov/pubmed/27543332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601278113
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