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Endocytosis is required for CXC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling
Signaling activated by binding of the CXC motif chemokine ligand 12 (CXCL12) to its cognate G protein–coupled receptor (GPCR), chemokine CXC motif receptor 4 (CXCR4), is linked to metastatic disease. However, the mechanisms governing CXCR4 signaling remain poorly understood. Here, we show that endoc...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6065176/ https://ncbi.nlm.nih.gov/pubmed/29899118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001872 |
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