The energetics and physiological impact of cohesin extrusion

Cohesin extrusion is thought to play a central role in establishing the architecture of mammalian genomes. However, extrusion has not been visualized in-vivo and thus its functional impact and energetics are unknown. Using ultra-deep Hi-C we show that loop domains form by a process that requires coh...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell
Autori principali: Vian, Laura, Pękowska, Aleksandra P, Rao, Suhas S.P., Kieffer-Kwon, Kyong-Rim, Jung, Seolkyoung, Baranello, Laura, Huang, Su-Chen, El Khattabi, Laila, Dose, Marei, Pruett, Nathanael, Sanborn, Adrian L., Canela, Andres, Maman, Yaakov, Oksanen, Anna, Resch, Wolfgang, Li, Xingwang, Lee, Byoungkoo, Kovalchuk, Alexander L., Tang, Zhonghui, Nelson, Steevenson, Pierro, Michele Di, Cheng, Ryan R., Machol, Ido, St Hilaire, Brian Glenn, Durand, Neva C., Shamim, Muhammad S., Stamenova, Elena K., Onuchic, José N., Ruan, Yijun, Nussenzweig, Andre, Levens, David, Aiden, Erez Lieberman, Casellas, Rafael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065110/
https://ncbi.nlm.nih.gov/pubmed/29706548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.072
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi