A three-dimensional map of the human genome at kilobase resolution reveals principles of chromatin looping

We use in situ Hi-C to probe the three-dimensional architecture of genomes, constructing haploid and diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 billion contacts, achieving 1-kilobase resolution. We find that genomes are partitioned into local domains, w...

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Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Rao, Suhas S.P., Huntley, Miriam H., Durand, Neva C., Stamenova, Elena K., Bochkov, Ivan D., Robinson, James T., Sanborn, Adrian, Machol, Ido, Omer, Arina D., Lander, Eric S., Aiden, Erez Lieberman
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635824/
https://ncbi.nlm.nih.gov/pubmed/25497547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.021
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