De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds

The Zika outbreak, spread by the Aedes aegypti mosquito, highlights the need to create high-quality assemblies of large genomes in a rapid and cost-effective way. Here we combine Hi-C data with existing draft assemblies to generate chromosome-length scaffolds. We validate this method by assembling a...

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Udgivet i:Science
Main Authors: Dudchenko, Olga, Batra, Sanjit S., Omer, Arina D., Nyquist, Sarah K., Hoeger, Marie, Durand, Neva C., Shamim, Muhammad S., Machol, Ido, Lander, Eric S., Aiden, Aviva Presser, Aiden, Erez Lieberman
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635820/
https://ncbi.nlm.nih.gov/pubmed/28336562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal3327
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