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Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes

We recently used in situ Hi-C to create kilobase-resolution 3D maps of mammalian genomes. Here, we combine these maps with new Hi-C, microscopy, and genome-editing experiments to study the physical structure of chromatin fibers, domains, and loops. We find that the observed contact domains are incon...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Sanborn, Adrian L., Rao, Suhas S. P., Huang, Su-Chen, Durand, Neva C., Huntley, Miriam H., Jewett, Andrew I., Bochkov, Ivan D., Chinnappan, Dharmaraj, Cutkosky, Ashok, Li, Jian, Geeting, Kristopher P., Gnirke, Andreas, Melnikov, Alexandre, McKenna, Doug, Stamenova, Elena K., Lander, Eric S., Aiden, Erez Lieberman
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664323/
https://ncbi.nlm.nih.gov/pubmed/26499245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518552112
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