The energetics and physiological impact of cohesin extrusion

Cohesin extrusion is thought to play a central role in establishing the architecture of mammalian genomes. However, extrusion has not been visualized in-vivo and thus its functional impact and energetics are unknown. Using ultra-deep Hi-C we show that loop domains form by a process that requires coh...

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Publicat a:Cell
Autors principals: Vian, Laura, Pękowska, Aleksandra P, Rao, Suhas S.P., Kieffer-Kwon, Kyong-Rim, Jung, Seolkyoung, Baranello, Laura, Huang, Su-Chen, El Khattabi, Laila, Dose, Marei, Pruett, Nathanael, Sanborn, Adrian L., Canela, Andres, Maman, Yaakov, Oksanen, Anna, Resch, Wolfgang, Li, Xingwang, Lee, Byoungkoo, Kovalchuk, Alexander L., Tang, Zhonghui, Nelson, Steevenson, Pierro, Michele Di, Cheng, Ryan R., Machol, Ido, St Hilaire, Brian Glenn, Durand, Neva C., Shamim, Muhammad S., Stamenova, Elena K., Onuchic, José N., Ruan, Yijun, Nussenzweig, Andre, Levens, David, Aiden, Erez Lieberman, Casellas, Rafael
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065110/
https://ncbi.nlm.nih.gov/pubmed/29706548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.072
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