The energetics and physiological impact of cohesin extrusion

Cohesin extrusion is thought to play a central role in establishing the architecture of mammalian genomes. However, extrusion has not been visualized in-vivo and thus its functional impact and energetics are unknown. Using ultra-deep Hi-C we show that loop domains form by a process that requires coh...

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Vydáno v:Cell
Hlavní autoři: Vian, Laura, Pękowska, Aleksandra P, Rao, Suhas S.P., Kieffer-Kwon, Kyong-Rim, Jung, Seolkyoung, Baranello, Laura, Huang, Su-Chen, El Khattabi, Laila, Dose, Marei, Pruett, Nathanael, Sanborn, Adrian L., Canela, Andres, Maman, Yaakov, Oksanen, Anna, Resch, Wolfgang, Li, Xingwang, Lee, Byoungkoo, Kovalchuk, Alexander L., Tang, Zhonghui, Nelson, Steevenson, Pierro, Michele Di, Cheng, Ryan R., Machol, Ido, St Hilaire, Brian Glenn, Durand, Neva C., Shamim, Muhammad S., Stamenova, Elena K., Onuchic, José N., Ruan, Yijun, Nussenzweig, Andre, Levens, David, Aiden, Erez Lieberman, Casellas, Rafael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065110/
https://ncbi.nlm.nih.gov/pubmed/29706548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.072
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