A three-dimensional map of the human genome at kilobase resolution reveals principles of chromatin looping

We use in situ Hi-C to probe the three-dimensional architecture of genomes, constructing haploid and diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 billion contacts, achieving 1-kilobase resolution. We find that genomes are partitioned into local domains, w...

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Bibliografiska uppgifter
I publikationen:Cell
Huvudupphovsmän: Rao, Suhas S.P., Huntley, Miriam H., Durand, Neva C., Stamenova, Elena K., Bochkov, Ivan D., Robinson, James T., Sanborn, Adrian, Machol, Ido, Omer, Arina D., Lander, Eric S., Aiden, Erez Lieberman
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635824/
https://ncbi.nlm.nih.gov/pubmed/25497547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.021
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