Scalable synthesis and validation of PAMAM dendrimer‐N‐acetyl cysteine conjugate for potential translation

Dendrimer‐N‐acetyl cysteine (D‐NAC) conjugate has shown significant promise in multiple preclinical models of brain injury and is undergoing clinical translation. D‐NAC is a generation‐4 hydroxyl‐polyamidoamine dendrimer conjugate where N‐acetyl cysteine (NAC) is covalently bound through disulfide l...

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Dades bibliogràfiques
Publicat a:Bioeng Transl Med
Autors principals: Sharma, Rishi, Sharma, Anjali, Kambhampati, Siva P., Reddy, Rajsekar Rami, Zhang, Zhi, Cleland, Jeffrey L., Kannan, Sujatha, Kannan, Rangaramanujam M.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063872/
https://ncbi.nlm.nih.gov/pubmed/30065965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btm2.10094
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